Clinical Trials

1,511 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT03050268 2026-02-09

SJFAMILY

BreastCNSClassical hematologyDermatologicEndocrineGastrointestinalGynecologicLymphoidOther solid neoplasmSarcoma

1,500 enrolled

Turcot syndrome, Juvenile polyposis syndrome, Choroid Plexus Carcinoma, GATA2 Deficiency, Basal Cell Nevus Syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Fanconi Anemia, Hamartoma Syndrome, Multiple, von Hippel-Lindau Disease, Hodgkin Disease, Lymphoma, Non-Hodgkin, Melanoma, Neuroblastoma, Neurofibromatosis 1, Noonan Syndrome, Pancreatic Neoplasms, Paraganglioma, Peutz-Jeghers Syndrome, Pheochromocytoma, Rothmund-Thomson Syndrome, Adenomatous Polyposis Coli, Retinoblastoma, Rhabdomyosarcoma, Tuberous Sclerosis, Neurofibromatosis 2, Li-Fraumeni Syndrome, Adrenocortical Carcinoma, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Dyskeratosis Congenita, Genetic Predisposition to Disease, Anemia, Diamond-Blackfan, Carney Complex, Hereditary Breast and Ovarian Cancer Syndrome

NCT04494945 2026-01-23

Identifying and Caring for Individuals With Inherited Cancer Syndrome

27,500 enrolled

Carcinoma, Intraductal, Noninfiltrating, Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT04261972 2026-01-14

CHARM1

Active not recruiting

1,416 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplasms, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT05721326 2026-01-13

Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition

1,330 enrolled

Breast Neoplasms, Neoplastic Syndromes, Hereditary, Ovarian Neoplasms, Genetic Predisposition to Disease, Genetic Diseases, Inborn, Hereditary Breast and Ovarian Cancer Syndrome

NCT04407611 2026-01-12

BWHS RoR

932 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT02760849 2026-01-07

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

374 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT06726642 2025-12-16

CHARM2

1,000 enrolled

Phase NA Not yet recruiting

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Stomach Neoplasms, Li-Fraumeni Syndrome, Hereditary Breast and Ovarian Cancer Syndrome

NCT07236359 2025-11-19

Reborn-i

108 enrolled

Breast Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT02302742 2025-10-06

PROGECT

1,500 enrolled

Breast Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome, Triple Negative Breast Neoplasms

NCT06892275 2025-09-30

The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI

80 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT03426878 2025-09-11

CHARM

967 enrolled 13 charts

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT05130606 2025-08-28

CONTIGO - A Narrative Intervention to Enhance Genetic Counseling and Testing

332 enrolled

Breast Neoplasms, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT02653105 2025-08-15

Women at Risk of Breast Cancer and OLFM4

150 enrolled

Phase NA Enrolling by invitation

Hereditary Breast and Ovarian Cancer Syndrome

NCT06914726 2025-08-05

PC-CDS

2,488 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Syndromes, Hereditary, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT06534424 2025-06-27

Clinical Impact of Enhanced Risk Assessments in Women With a BRCA1/2 Mutation, CARE Study

152 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT07039552 2025-06-26

Development and Validation of an Ovarian Cancer Risk Prediction Model for Family Members of Ovarian Cancer Probands

10,000 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT00005095 2025-02-28

Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

6,000 enrolled

BreastGynecologicSarcoma

Carcinoma, Ovarian Epithelial, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Sarcoma, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Myofibroma, Hereditary Breast and Ovarian Cancer Syndrome

NCT03124212 2025-02-14

CASCADE

700 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT03246841 2024-12-12

TUMOSPEC

7,274 enrolled

Phase EARLY_PHASE1 Completed

Breast Neoplasms, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT03832985 2024-11-05

Pediatric Reporting of Adult-Onset Genomic Results

427 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hyperlipoproteinemia Type II, Hereditary Breast and Ovarian Cancer Syndrome

NCT03510689 2024-10-16

Gene-HEART

79 enrolled

Breast Neoplasms, Heart Diseases, Hereditary Breast and Ovarian Cancer Syndrome

NCT01445275 2024-08-21

Cost of Cancer Risk Management in Women at Elevated Genetic Risk for Ovarian Cancer Who Participated on GOG-0199

Withdrawn

Fallopian Tube Neoplasms, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT04197856 2024-07-09

DIRECT

490 enrolled

Breast Cancer, Familial, Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT02087592 2024-04-16

LIBRE

69 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT04508764 2024-04-16

Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch Syndrome

Phase NA Terminated

96 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT02516540 2024-04-11

LIBRE-2

600 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT05306002 2024-03-05

Nutritional Intervention and DNA Damage of Patients With HBOC

34 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT04668521 2023-12-26

OVA360

Terminated

215 enrolled

BreastGenitourinaryGynecologic

Hereditary Breast and Ovarian Cancer Syndrome

NCT02203513 2022-09-10

A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

Phase 2 Terminated

111 enrolled 15 charts

Breast Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT05409222 2022-06-08

BRCA-HRT

Unknown

45 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT04544501 2022-05-02

Enhance the Use of Genetic Counseling and Testing in Latinas

61 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT03511690 2022-04-25

Testing an Intelligent Tutoring System to Enhance Genetic Risk Assessment

95 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT02705924 2021-11-30

Impact of a Psychoeducational Intervention on Expectations and Coping in Young Women Exposed to a High HBOC Risk

Phase NA Terminated

32 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT03784859 2020-10-06

Tissue Expansion in Breast Reconstruction Without Drains

5 enrolled

Breast Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT00305695 2020-03-24

Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries

Phase 2 Completed

160 enrolled 10 charts

Osteoporosis, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT03075540 2019-12-12

Enhancing At-risk Latina Women's Use of Genetic Counseling for Hereditary Breast and Ovarian Cancer

88 enrolled

Hereditary Breast and Ovarian Cancer Syndrome

NCT02451735 2019-11-08

Genetic Counseling for Breast Cancer Survivors (GC for BC)

157 enrolled

Breast Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome, Triple Negative Breast Neoplasms

NCT03979612 2019-06-07

GENEPY

Unknown

450 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Disease Susceptibility, Neoplasms, Neoplastic Syndromes, Hereditary, Hereditary Breast and Ovarian Cancer Syndrome

NCT03421327 2019-02-07

Genetic Risk: Whether, When, and How to Tell Adolescents

85 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Huntington Disease, Hereditary Breast and Ovarian Cancer Syndrome

NCT03015376 2018-11-14

Inherited Susceptible Genes Among Epithelial Ovarian Cancer

Unknown

1,000 enrolled

Carcinoma, Ovarian Epithelial, Hereditary Breast and Ovarian Cancer Syndrome

NCT03162276 2018-09-07

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Phase 3 Unknown

118 enrolled

BreastGastrointestinalGenitourinaryGynecologic

Hereditary Breast and Ovarian Cancer Syndrome

NCT00892736 2018-06-29

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Phase 1 Completed

98 enrolled

Breast Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome, Triple Negative Breast Neoplasms

NCT02786147 2018-04-20

Identification and Referral of Women at Risk for Hereditary Breast/Ovarian Cancer

665 enrolled

Breast Neoplasms, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT03294343 2017-12-26

Risk-Reducing Surgeries for Hereditary Ovarian Cancer

Phase NA Unknown

600 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome

NCT00685256 2017-05-17

Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children

Phase 3 Completed

245 enrolled

Breast Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT00829959 2016-08-04

Attitudes About Childbearing And Fertility With Inherited Breast And Ovarian Cancer Syndromes (HBOC)

156 enrolled

Breast Neoplasms, Ovarian Neoplasms, Hereditary Breast and Ovarian Cancer Syndrome

NCT02562170 2015-09-29

Protexa® Versus TiLoopBra® in Immediate Breast Reconstruction- A Pilot Study

Phase 4 Completed

50 enrolled