Clinical Trials

Phase EARLY_PHASE1 Recruiting

10,000 enrolled

Pediatric acute-onset neuropsychiatric syndrome, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections, Brain Injuries, Traumatic, Phobia, Social, Post-Lyme Disease Syndrome, Avoidant Restrictive Food Intake Disorder, Mast Cell Activation Syndrome, Neuroinflammatory Diseases, Psychological Well-Being, Post-Acute COVID-19 Syndrome, Generalized Anxiety Disorder, Anorexia Nervosa, Anxiety Disorders, Arthritis, Juvenile, Autoimmune Diseases, Autonomic Nervous System Diseases, Mental Disorders, Celiac Disease, Colitis, Ulcerative, Combat Disorders, Crohn Disease, Depression, Ehlers-Danlos Syndrome, Encephalitis, Endometriosis, Fatigue, Mental Fatigue, Fibromyalgia, Tourette Syndrome, Migraine Disorders, Multiple Sclerosis, Myasthenia Gravis, Narcolepsy, Obsessive-Compulsive Disorder, Psoriasis, Rheumatic Fever, Spondylitis, Ankylosing, Stress Disorders, Post-Traumatic, Inflammatory Bowel Diseases, Arthritis, Psoriatic, Fatigue Syndrome, Chronic, Mood Disorders, Autoimmune Diseases of the Nervous System, Bulimia Nervosa, Postural Orthostatic Tachycardia Syndrome

NCT07337785 2026-01-22

CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases

36 enrolled

Multiple Sclerosis, Myasthenia Gravis, Recurrence, Autoimmune Diseases of the Nervous System, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT07333196 2026-01-21

Tongji NADs Cohort

Not yet recruiting

1,550 enrolled

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, Multiple Sclerosis, Myasthenia Gravis, Myositis, Neuromyelitis Optica, Autoimmune Diseases of the Nervous System, Guillain-Barre Syndrome, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT04306939 2026-01-07

GREAT1

Suspended

120,000 enrolled

Gastrointestinal

Arthritis, Rheumatoid, Celiac Disease, Cholecystitis, Cholelithiasis, Chronic Disease, Crohn Disease, Cystic Fibrosis, Diabetes Mellitus, Fibrosis, Gastritis, Hepatitis, Liver Cirrhosis, Biliary, Multiple Sclerosis, Pancreatic Cyst, Exocrine Pancreatic Insufficiency, Pancreatitis, Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Dyslipidemias, Pancreatitis, Chronic, Renal Insufficiency, Chronic, Chronic Pain, Non-alcoholic Fatty Liver Disease

NCT06788886 2025-12-30

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

Phase NA Recruiting

147 enrolled

CNSEndocrineGenitourinaryNET

Brain Neoplasms, Multiple Sclerosis, Prostatic Neoplasms, Neuroendocrine Tumors

NCT06322342 2025-12-26

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Phase 2 Completed

18 enrolled

Other hematologic neoplasmPlasma cell

Neuroinflammatory Diseases, Brain Neoplasms, Glioma, Meningioma, Multiple Sclerosis, Neoplasms, Neurilemmoma, Neurofibroma, Neuroma, Acoustic, Central Nervous System Neoplasms

NCT04952766 2025-12-23

EREVA

Phase 4 Completed

196 enrolled

Acquired Immunodeficiency Syndrome, Diabetes Mellitus, Type 2, Hypergammaglobulinemia, Multiple Sclerosis, Neoplasms, Hematologic Neoplasms, Neoplasms, Plasma Cell

NCT06939166 2025-12-15

Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases

Phase EARLY_PHASE1 Recruiting

12 enrolled

Multiple Sclerosis, Myasthenia Gravis, Neuromyelitis Optica, Autoimmune Diseases of the Nervous System, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT00445367 2025-10-02

Biobank For MS And Other Demyelinating Diseases

Active not recruiting

3,226 enrolled

Encephalomyelitis, Acute Disseminated, Multiple Sclerosis, Myelitis, Transverse, Neuromyelitis Optica, Optic Neuritis

NCT02670161 2025-08-24

Quality Improvement and Practice Based Research in Neurology Using the EMR

Phase 4 Enrolling by invitation

3,300 enrolled

GastrointestinalOtherOther solid neoplasmThoracic

Brain Concussion, Brain Neoplasms, Epilepsy, Migraine Disorders, Multiple Sclerosis, Parkinson Disease, Restless Legs Syndrome, Stroke, Cognitive Dysfunction

NCT04031469 2025-07-31

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease

Suspended

1,000 enrolled

Autism Spectrum Disorder, Bipolar and Related Disorders, Post-Lyme Disease Syndrome, Generalized Anxiety Disorder, Acne Vulgaris, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Anxiety Disorders, Arthritis, Rheumatoid, Autistic Disorder, Bipolar Disorder, Celiac Disease, Colitis, Ulcerative, Colonic Neoplasms, Compulsive Personality Disorder, Constipation, Crohn Disease, Depression, Depressive Disorder, Major, Diabetes Mellitus, Eczema, Epidermolysis Bullosa, Gout, Hypercholesterolemia, Lyme Disease, Mesothelioma, Migraine Disorders, Multiple Sclerosis, Myasthenia Gravis, Neoplasms, Obsessive-Compulsive Disorder, Parkinson Disease, Psoriasis, Colorectal Neoplasms, Fatigue Syndrome, Chronic, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Lyme Neuroborreliosis, Irritable Bowel Syndrome

NCT06869278 2025-06-11

A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases

Phase 1 Recruiting

37 enrolled

Multiple Sclerosis, Myasthenia Gravis, Recurrence

NCT00704626 2025-05-15

SAA

Enrolling by invitation

120 enrolled

Autoimmune Diseases, Multiple Sclerosis, Myasthenia Gravis, Myelitis, Transverse

NCT05815108 2025-05-08

EBV-RIS

156 enrolled

Multiple Sclerosis, Epstein-Barr Virus Infections

NCT06940323 2025-05-04

Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

250 enrolled

Multiple Sclerosis, Myasthenia Gravis

NCT06203106 2025-03-03

NYSCF Scientific Discovery Biobank

Phase EARLY_PHASE1 Not yet recruiting

10,000 enrolled

Gynecologic

Corticobasal Degeneration, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Uterine Cervical Neoplasms, Dementia, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Huntington Disease, Macular Degeneration, Multiple Sclerosis, Neuronal Ceroid-Lipofuscinoses, Ovarian Neoplasms, Parkinson Disease, Stress Disorders, Post-Traumatic, Supranuclear Palsy, Progressive, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Multiple System Atrophy, Parkinsonian Disorders, Lewy Body Disease, Frontotemporal Dementia

NCT06112639 2025-01-10

DANCEREX-DTx

Phase NA Recruiting

192 enrolled

Lymphoid

Neuroinflammatory Diseases, Cognition Disorders, Dementia, Lymphoma, Follicular, Multiple Sclerosis

NCT06485232 2025-01-01

Universal CAR-T Cells in Patients with Refractory Autoimmune Diseases of the Nervous System.

25 enrolled

Multiple Sclerosis, Myasthenia Gravis, Neuromyelitis Optica, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT05017142 2024-12-16

Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)

500 enrolled

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, Encephalitis, Encephalomyelitis, Acute Disseminated, Multiple Sclerosis, Myelitis, Transverse, Neuromyelitis Optica, Optic Neuritis, Autoimmune Diseases of the Nervous System, Vasculitis, Central Nervous System, Lupus Vasculitis, Central Nervous System, Anti-N-Methyl-D-Aspartate Receptor Encephalitis

NCT06502015 2024-11-20

Biomarkers in Autoimmune Disease of Nervous System

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

50,000 enrolled

Autoimmune Diseases, Encephalomyelitis, Acute Disseminated, Multiple Sclerosis, Myasthenia Gravis, Myositis, Neuromyelitis Optica, Stiff-Person Syndrome, Autoimmune Diseases of the Nervous System, Guillain-Barre Syndrome, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT06583395 2024-11-01

QUANTUM

Enrolling by invitation

3,000 enrolled

Amyotrophic Lateral Sclerosis, Anxiety Disorders, Arthritis, Rheumatoid, Asthma, Atrial Fibrillation, Brain Neoplasms, Breast Neoplasms, Cerebral Palsy, Cluster Headache, Colitis, Ulcerative, Colonic Neoplasms, Crohn Disease, Deafness, Depression, Diabetes Mellitus, Eczema, Epilepsy, Fibromyalgia, Heart Failure, Hypertension, Hyperthyroidism, Hypothyroidism, Infertility, Leiomyoma, Lung Neoplasms, Lyme Disease, Lymphoma, Macular Degeneration, Migraine Disorders, Multiple Sclerosis, Neoplasms, Osteoarthritis, Osteoporosis, Ovarian Cysts, Ovarian Neoplasms, Parkinson Disease, Phantom Limb, Prostatic Neoplasms, Psoriasis, Skin Neoplasms, Spinal Cord Injuries, Spinal Stenosis, Stress Disorders, Post-Traumatic, Thyroid Neoplasms, Tinnitus, Fatigue Syndrome, Chronic, Tension-Type Headache, Stroke, Pulmonary Disease, Chronic Obstructive, Irritable Bowel Syndrome, Renal Insufficiency, Chronic, Angina, Stable

NCT06136923 2024-05-13

An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer

194 enrolled

BreastThoracic

Breast Neoplasms, Lung Neoplasms, Multiple Sclerosis

NCT05819008 2024-05-09

Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries

350 enrolled

Brain Injuries, Traumatic, Brain Neoplasms, Epilepsy, Multiple Sclerosis, Parkinson Disease, Stroke

NCT05635266 2024-05-07

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Classical hematologyGenitourinaryHead & NeckLymphoidOther hematologic neoplasmPlasma cell

20,000 enrolled

red meat allergy, Alopecia Areata, Alzheimer Disease, Amyloidosis, Anemia, Sickle Cell, Arthritis, Asthma, Autistic Disorder, Behcet Syndrome, Celiac Disease, Colitis, Ulcerative, Crohn Disease, Cystic Fibrosis, Dermatitis, Atopic, Diabetes Mellitus, Epilepsies, Myoclonic, Fibrosis, Fibromyalgia, Graves Disease, Heart Diseases, Hepatitis, Hypersensitivity, Kidney Diseases, Leukemia, Lupus Erythematosus, Systemic, Lymphoma, Macular Degeneration, Multiple Sclerosis, Myasthenia Gravis, Neoplasms, Parkinson Disease, Pemphigus, Psoriasis, Schizophrenia, Spondylitis, Ankylosing, Thyroid Diseases, Vasculitis, Vitiligo, beta-Thalassemia, Hidradenitis Suppurativa, Hepatitis, Autoimmune, Stroke, Pulmonary Disease, Chronic Obstructive, Scleroderma, Diffuse

NCT06330298 2024-04-16

T-ScEmo4ALL

Phase NA Recruiting

84 enrolled

Brain Neoplasms, Multiple Sclerosis, Nervous System Diseases, Social Behavior, Stroke

NCT03283826 2024-02-23

EMBOLD

Phase 1/2 Terminated

134 enrolled

Autoimmune Diseases, Demyelinating Diseases, Inflammation, Multiple Sclerosis, Epstein-Barr Virus Infections, Multiple Sclerosis, Chronic Progressive

NCT06251830 2024-02-09

Increasing Diagnosis Rates While Reducing Examination Time: Can MR Fingerprinting Deliver on Its Promise?

610 enrolled

CNSDermatologicOtherThoracic

Brain Neoplasms, Epilepsy, Multiple Sclerosis, Neurodegenerative Diseases, Neurodevelopmental Disorders

NCT03840928 2023-12-13

PatientSpot Formerly Known as ArthritisPower

Unknown

40,000 enrolled

Intervertebral disc disease, Undifferentiated Connective Tissue Diseases, Axial Spondyloarthritis, Alopecia, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Angina, Unstable, Arrhythmias, Cardiac, Arthritis, Juvenile, Arthritis, Rheumatoid, Asthma, Ataxia, Brain Neoplasms, Intracranial Aneurysm, Cluster Headache, Crohn Disease, Cystic Fibrosis, Dermatomyositis, Diabetes Mellitus, Hyperostosis, Diffuse Idiopathic Skeletal, Eczema, Epilepsy, Fibromyalgia, Gout, Craniocerebral Trauma, Headache, Heart Defects, Congenital, Heart Failure, Heart Valve Diseases, Hydrocephalus, Hypertension, Lung Neoplasms, Meningitis, Multiple Sclerosis, Muscular Dystrophies, Myocardial Infarction, Myositis, Obesity, Osteoarthritis, Osteoporosis, Parkinson Disease, Polychondritis, Relapsing, Polymyalgia Rheumatica, Psoriasis, Sleep Apnea Syndromes, Spinal Cord Injuries, Spondylitis, Ankylosing, Giant Cell Arteritis, Granulomatosis with Polyangiitis, Inflammatory Bowel Diseases, Arthritis, Psoriatic, Polymyositis, Tension-Type Headache, Guillain-Barre Syndrome, Bell Palsy, Stroke, Neurocutaneous Syndromes, Pulmonary Disease, Chronic Obstructive, Scleroderma, Diffuse, Peripheral Arterial Disease

NCT05945784 2023-12-06

Exploring Accessible Beauty for Individuals With Upper Extremity Deficits

Classical hematologyOther

57 enrolled

Brain Injuries, Traumatic, Ischemic Stroke, Hemorrhagic Stroke, Amyotrophic Lateral Sclerosis, Ehlers-Danlos Syndrome, Graves Disease, Multiple Sclerosis, Muscular Dystrophies, Myasthenia Gravis, Spinal Cord Injuries, Muscle Weakness, Guillain-Barre Syndrome, Stroke

NCT06072287 2023-10-12

LTC

Unknown

600 enrolled

Psychological Well-Being, Post-Acute COVID-19 Syndrome, Acquired Immunodeficiency Syndrome, Amyotrophic Lateral Sclerosis, Anemia, Sickle Cell, Anxiety Disorders, Arthritis, Arthritis, Rheumatoid, Asthma, Atrial Fibrillation, Celiac Disease, Cerebrovascular Disorders, Chronic Disease, Cystic Fibrosis, Dementia, Depression, Diabetes Mellitus, Eczema, Endometriosis, Epilepsy, Fibromyalgia, Heart Diseases, Heart Failure, Hepatitis, Hypertension, Liver Diseases, Migraine Disorders, Multiple Sclerosis, Neoplasms, Nervous System Diseases, Obesity, Osteoarthritis, Osteoporosis, Pain, Parkinson Disease, Spondylitis, Fatigue Syndrome, Chronic, Hidradenitis Suppurativa, Stroke, Pulmonary Disease, Chronic Obstructive, Postural Orthostatic Tachycardia Syndrome

NCT03942952 2023-09-05

SONICS

49 enrolled

Encephalomyelitis, Acute Disseminated, Multiple Sclerosis, Myelitis, Transverse, Neuromyelitis Optica, Multiple Sclerosis, Relapsing-Remitting

NCT02486640 2023-07-24

BETAPREDICT

162 enrolled

Carcinoma in Situ, Multiple Sclerosis

NCT05438147 2023-04-26

Effects of a CT-100 DiNaMo Component on Cognitive Functioning and Mood Symptoms

114 enrolled

Multiple Sclerosis, Neoplasms, Cognitive Dysfunction

NCT03656627 2023-02-15

Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease

Phase 1 Terminated

7 enrolled

Thoracic

Arthritis, Rheumatoid, Autoimmune Diseases, Carcinoma, Non-Small-Cell Lung, Colitis, Ulcerative, Crohn Disease, Lupus Erythematosus, Systemic, Multiple Sclerosis, Polymyalgia Rheumatica, Psoriasis, Giant Cell Arteritis

NCT04844489 2023-02-06

COVIVAC-ID

377 enrolled

COVID-19, Multiple Sclerosis, Neoplasms

NCT02073474 2022-12-20

An Observational Post-Marketing Safety Registry of Sativex®

978 enrolled

Marijuana Abuse, Diabetes Mellitus, Multiple Sclerosis, Neoplasms, Neuralgia

NCT03944447 2022-06-02

OMNI-Can

Phase 2 Unknown

200,000 enrolled

Classical hematology

Chronic Traumatic Encephalopathy, Brain Injuries, Traumatic, COVID-19, Acquired Immunodeficiency Syndrome, Amyotrophic Lateral Sclerosis, Anemia, Sickle Cell, Anxiety Disorders, Autistic Disorder, Bipolar Disorder, Colitis, Ulcerative, Crohn Disease, Depression, Epilepsy, Fibromyalgia, Tourette Syndrome, Glaucoma, Hepatitis C, Sleep Initiation and Maintenance Disorders, Multiple Sclerosis, Opioid-Related Disorders, Neoplasms, Parkinson Disease, Seizures, Stress Disorders, Post-Traumatic, Inflammatory Bowel Diseases, Coronavirus Infections, Severe Acute Respiratory Syndrome, Chronic Pain

NCT03154801 2022-02-18

NEUROSEX

Phase NA Unknown

54 enrolled

Multiple Sclerosis

NCT03826056 2022-01-11

Neurology Inpatient Clinical Education Trial

50 enrolled

Encephalitis, Headache, Hydrocephalus, Normal Pressure, Meningitis, Multiple Sclerosis, Myasthenia Gravis, Seizures, Vestibular Diseases, Guillain-Barre Syndrome, Parkinsonian Disorders, Spondylosis

NCT03941184 2020-11-23

Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Classical hematologyGastrointestinal

114 enrolled

Coronary Artery Dissection, Spontaneous, Addison Disease, Anemia, Pernicious, Arthritis, Rheumatoid, Celiac Disease, Colitis, Ulcerative, Crohn Disease, Dermatomyositis, Diabetes Mellitus, Type 1, Graves Disease, Liver Cirrhosis, Biliary, Lupus Erythematosus, Systemic, Multiple Sclerosis, Myasthenia Gravis, Polymyalgia Rheumatica, Psoriasis, Scleroderma, Systemic, Sjogren's Syndrome, Spondylitis, Ankylosing, Takayasu Arteritis, Uveitis, Vasculitis, Vitiligo, Antiphospholipid Syndrome, Polymyositis, Hepatitis, Autoimmune, Guillain-Barre Syndrome, Hashimoto Disease

NCT03456206 2020-11-10

PROCID-DCH

Unknown

57,053 enrolled

Arthritis, Rheumatoid, Autoimmune Diseases, Colitis, Ulcerative, Crohn Disease, Multiple Sclerosis, Psoriasis, Inflammatory Bowel Diseases, Arthritis, Psoriatic, Spondylarthropathies

NCT03886753 2020-07-30

Ilera

Terminated

10 enrolled

Classical hematology

Autism Spectrum Disorder, Acquired Immunodeficiency Syndrome, Anemia, Sickle Cell, Epilepsy, Glaucoma, Huntington Disease, Multiple Sclerosis, Muscle Spasticity, Neoplasms, Pain, Intractable, Parkinson Disease, Stress Disorders, Post-Traumatic, Inflammatory Bowel Diseases, Dyskinesias

NCT03847753 2020-05-22

COMO-GMC