Clinical Trials Browser

Interventional × Multiple Sclerosis × Clear all

NCT03816345 2026-03-18

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

Arthritis, Rheumatoid, Autoimmune Diseases, Colitis, Ulcerative, Crohn Disease, Dermatomyositis, Lupus Erythematosus, Systemic, Multiple Sclerosis, Psoriasis, Scleroderma, Systemic, Sjogren's Syndrome, Inflammatory Bowel Diseases, Arthritis, Psoriatic, Hematologic Neoplasms

NCT07002034 2026-03-16

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

Phase 2 Recruiting

100 enrolled

Adjustment Disorders, Amyotrophic Lateral Sclerosis, Anxiety Disorders, Depression, Multiple Sclerosis, Neoplasms, Idiopathic Pulmonary Fibrosis

NCT07304154 2026-03-10

A Study Evaluating the Safety and Efficacy of KITE-363 in Relapsed/Refractory Autoimmune Neurologic Diseases

Phase 1 Not yet recruiting

52 enrolled

Multiple Sclerosis, Myasthenia Gravis, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT06680037 2026-02-27

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

Phase 1 Recruiting

32 enrolled

Multiple Sclerosis, Myasthenia Gravis, Neuromyelitis Optica, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT07392528 2026-02-11

Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/ BCMA（QT-019C） in Patients With r/ r Neurological Autoimmune Diseases

Phase EARLY_PHASE1 Not yet recruiting

15 enrolled

Multiple Sclerosis, Myasthenia Gravis, Neuromyelitis Optica

NCT06220201 2026-02-10

A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

Phase 1 Recruiting

120 enrolled

Multiple Sclerosis, Myasthenia Gravis

NCT07337785 2026-01-22

CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases

Phase EARLY_PHASE1 Recruiting

36 enrolled

Multiple Sclerosis, Myasthenia Gravis, Recurrence, Autoimmune Diseases of the Nervous System, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT06788886 2025-12-30

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

Phase NA Recruiting

147 enrolled

CNSEndocrineGenitourinaryNET

Brain Neoplasms, Multiple Sclerosis, Prostatic Neoplasms, Neuroendocrine Tumors

NCT06322342 2025-12-26

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Phase 2 Completed

18 enrolled

CNS

Neuroinflammatory Diseases, Brain Neoplasms, Glioma, Meningioma, Multiple Sclerosis, Neoplasms, Neurilemmoma, Neurofibroma, Neuroma, Acoustic, Central Nervous System Neoplasms

NCT04952766 2025-12-23

EREVA

Phase 4 Completed

196 enrolled

Other hematologic neoplasmPlasma cell

Acquired Immunodeficiency Syndrome, Diabetes Mellitus, Type 2, Hypergammaglobulinemia, Multiple Sclerosis, Neoplasms, Hematologic Neoplasms, Neoplasms, Plasma Cell

NCT06939166 2025-12-15

Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases

Phase EARLY_PHASE1 Recruiting

12 enrolled

Multiple Sclerosis, Myasthenia Gravis, Neuromyelitis Optica, Autoimmune Diseases of the Nervous System, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT02670161 2025-08-24

Quality Improvement and Practice Based Research in Neurology Using the EMR

Phase 4 Enrolling by invitation

3,300 enrolled

CNS

Brain Concussion, Brain Neoplasms, Epilepsy, Migraine Disorders, Multiple Sclerosis, Parkinson Disease, Restless Legs Syndrome, Stroke, Cognitive Dysfunction

NCT06869278 2025-06-11

A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases

Phase 1 Recruiting

37 enrolled

Multiple Sclerosis, Myasthenia Gravis, Recurrence

NCT06112639 2025-01-10

DANCEREX-DTx

Phase NA Recruiting

192 enrolled

Lymphoid

Neuroinflammatory Diseases, Cognition Disorders, Dementia, Lymphoma, Follicular, Multiple Sclerosis

NCT06485232 2025-01-01

Universal CAR-T Cells in Patients with Refractory Autoimmune Diseases of the Nervous System.

Phase EARLY_PHASE1 Not yet recruiting

25 enrolled

Multiple Sclerosis, Myasthenia Gravis, Neuromyelitis Optica, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT04561557 2024-10-30

CARTinNS

Phase EARLY_PHASE1 Recruiting

36 enrolled

Plasma cell

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, Autoimmune Diseases, Multiple Sclerosis, Myasthenia Gravis, Myositis, Neuromyelitis Optica, POEMS Syndrome, Autoimmune Diseases of the Nervous System, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

NCT06136923 2024-05-13

An Exploratory Study to Evaluate Attention Biases in Adults With Multiple Sclerosis, Breast Cancer, and Lung Cancer

Phase NA Completed

194 enrolled

BreastThoracic

Breast Neoplasms, Lung Neoplasms, Multiple Sclerosis

NCT06330298 2024-04-16

T-ScEmo4ALL

Phase NA Recruiting

84 enrolled

CNS

Brain Neoplasms, Multiple Sclerosis, Nervous System Diseases, Social Behavior, Stroke

NCT03283826 2024-02-23

EMBOLD

Phase 1/2 Terminated

134 enrolled

Autoimmune Diseases, Demyelinating Diseases, Inflammation, Multiple Sclerosis, Epstein-Barr Virus Infections, Multiple Sclerosis, Chronic Progressive

NCT05438147 2023-04-26

Effects of a CT-100 DiNaMo Component on Cognitive Functioning and Mood Symptoms

Phase NA Completed

114 enrolled

Multiple Sclerosis, Neoplasms, Cognitive Dysfunction

NCT03656627 2023-02-15

Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease

Phase 1 Terminated

7 enrolled

Thoracic

Arthritis, Rheumatoid, Autoimmune Diseases, Carcinoma, Non-Small-Cell Lung, Colitis, Ulcerative, Crohn Disease, Lupus Erythematosus, Systemic, Multiple Sclerosis, Polymyalgia Rheumatica, Psoriasis, Giant Cell Arteritis

NCT04844489 2023-02-06

COVIVAC-ID

Phase NA Completed

377 enrolled

COVID-19, Multiple Sclerosis, Neoplasms

NCT03944447 2022-06-02

OMNI-Can

Phase 2 Unknown

200,000 enrolled

Classical hematology

Chronic Traumatic Encephalopathy, Brain Injuries, Traumatic, COVID-19, Acquired Immunodeficiency Syndrome, Amyotrophic Lateral Sclerosis, Anemia, Sickle Cell, Anxiety Disorders, Autistic Disorder, Bipolar Disorder, Colitis, Ulcerative, Crohn Disease, Depression, Epilepsy, Fibromyalgia, Tourette Syndrome, Glaucoma, Hepatitis C, Sleep Initiation and Maintenance Disorders, Multiple Sclerosis, Opioid-Related Disorders, Neoplasms, Parkinson Disease, Seizures, Stress Disorders, Post-Traumatic, Inflammatory Bowel Diseases, Coronavirus Infections, Severe Acute Respiratory Syndrome, Chronic Pain

NCT03154801 2022-02-18

NEUROSEX

Phase NA Unknown

54 enrolled

Multiple Sclerosis

NCT03826056 2022-01-11

Neurology Inpatient Clinical Education Trial

Phase NA Completed

50 enrolled

Encephalitis, Headache, Hydrocephalus, Normal Pressure, Meningitis, Multiple Sclerosis, Myasthenia Gravis, Seizures, Vestibular Diseases, Guillain-Barre Syndrome, Parkinsonian Disorders, Spondylosis

NCT02591901 2020-03-18

PReSuTINeB

Phase 2 Completed

48 enrolled

Genitourinary

Urinary Bladder, Neurogenic, Multiple Sclerosis, Myelitis, Transverse, Spinal Cord Injuries, Urinary Tract Infections

NCT02767609 2019-04-30

Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging

Phase NA Completed

1 enrolled 4 charts

Brain Injuries, Traumatic, Alzheimer Disease, Multiple Sclerosis, Neoplasms

NCT03138421 2019-01-25

Central Pain Study for ABX-1431

Phase 1 Completed

9 enrolled

Multiple Sclerosis, Myelitis, Transverse, Neuromyelitis Optica

NCT01416181 2017-09-11

ASCEND in SPMS

Phase 3 Terminated

889 enrolled 31 charts

Multiple Sclerosis, Neoplasm Metastasis, Multiple Sclerosis, Chronic Progressive

NCT00179478 2017-09-06

CHAMPIONS10

Phase 4 Completed

155 enrolled 10 charts

Cerebellar Diseases, Multiple Sclerosis, Myelitis, Transverse, Optic Neuritis

NCT02967380 2017-03-27

Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases

Phase NA Terminated

14 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Multiple Sclerosis, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT02858778 2016-08-08

Timing of Acute Palliative Care Consultation in Critically Ill Patients

Phase NA Unknown

120 enrolled

Dementia, Emergencies, Hepatic Encephalopathy, Multiple Organ Failure, Multiple Sclerosis, Parkinson Disease, Sepsis, Renal Insufficiency, Chronic

NCT02777060 2016-05-19

Exploring the Effectiveness of Sensor-based Balance Training on Patient Outcome Measures

Phase NA Unknown

200 enrolled

Arthritis, Brain Injuries, Diabetes Mellitus, Multiple Sclerosis, Neoplasms, Parkinson Disease, Stroke, Cognitive Dysfunction

NCT00004645 2005-06-24

Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone

Phase 3 Unknown

22 enrolled

Mental Disorders, Diffuse Cerebral Sclerosis of Schilder, Encephalomyelitis, Acute Disseminated, Multiple Sclerosis, Myelitis, Transverse, Neurologic Manifestations, Neuromyelitis Optica, Rare Diseases