Clinical Trials

Phase EARLY_PHASE1 Active not recruiting

90 enrolled

Peripheral Nervous System Diseases, Neurotoxicity Syndromes

NCT04514029 2026-01-08

Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel

37 enrolled

Phase 1 Active not recruiting

Lymphoma, Neurotoxicity Syndromes

NCT03696784 2025-12-08

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

19 enrolled

Phase NA Active not recruiting

Cytokine Release Syndrome, Immune System Diseases, Immunoproliferative Disorders, Lymphatic Diseases, Lymphoma, Lymphoma, B-Cell, Neurotoxicity Syndromes

NCT05025826 2025-12-02

PROPERTY

110 enrolled

Stomach Neoplasms, Neurotoxicity Syndromes

NCT04150913 2025-11-25

A Phase 2 Trial of Anakinra for the Prevention of CAR-T Cell Mediated Neurotoxicity

15 enrolled 17 charts

Cytokine Release Syndrome, Lymphoma, Non-Hodgkin, Neurotoxicity Syndromes

NCT00727922 2025-11-20

MnDPDP-K04

23 enrolled

Neoplasms, Neurotoxicity Syndromes

NCT04583124 2025-11-18

ATENTO

Phase NA Completed

42 enrolled

Phase 3 Active not recruiting

Breast Neoplasms, Neurotoxicity Syndromes

NCT00978458 2025-09-08

Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma

540 enrolled

Phase 3 Enrolling by invitation

Astrocytoma, Brain Neoplasms, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Neurotoxicity Syndromes

NCT06950190 2025-08-12

(ECCPC)

100 enrolled

Chemotherapy-Related Cognitive Impairment, Neurotoxicity Syndromes, Cognitive Dysfunction

NCT06551051 2024-09-19

ADC-induced Neurotoxicity Treated With Duloxetine

Phase 2 Recruiting

37 enrolled

Neurotoxicity Syndromes

NCT01399372 2023-07-20

Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

91 enrolled 17 charts

Lymphoma, Radiation Injuries, Neurotoxicity Syndromes

NCT05798884 2023-04-05

Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients

Phase NA Unknown

150 enrolled

Colorectal Neoplasms, Neurotoxicity Syndromes

NCT00660842 2023-03-24

MITO-7

Phase 3 Unknown

800 enrolled

Gynecologic

Ovarian Neoplasms, Neurotoxicity Syndromes

NCT01372774 2022-09-16

Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery

194 enrolled 11 charts

Brain Neoplasms, Neoplasm Metastasis, Radiation Injuries, Neurotoxicity Syndromes

NCT05494320 2022-08-09

the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin

Unknown

120 enrolled

Gastrointestinal Neoplasms, Neurotoxicity Syndromes

NCT00039780 2022-07-13

Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly Paclitaxel

764 enrolled

Breast Diseases, Breast Neoplasms, Neoplasm Metastasis, Neoplasms, Paresthesia, Neurotoxicity Syndromes

NCT00792142 2021-08-19

Bortezomib, Thalidomide, and Dexamethasone After Melphalan and Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma

45 enrolled 8 charts

Plasma cell

Multiple Myeloma, Neurotoxicity Syndromes, Neoplasms, Plasma Cell

NCT01381718 2021-08-13

Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor

112 enrolled 16 charts

Fatigue, Central Nervous System Neoplasms, Neurotoxicity Syndromes

NCT02864030 2021-03-04

PAINTER: Polymorphism And INcidence of Toxicity in ERibulin Treatment

Phase 4 Completed

200 enrolled

Breast Neoplasms, Neurotoxicity Syndromes, Drug-Related Side Effects and Adverse Reactions

NCT01913093 2020-10-08

NPG

LymphoidOther hematologic neoplasm

204 enrolled

Leukemia, Neurotoxicity Syndromes, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02890030 2020-04-08

The Platinum Study Comparison Group

102 enrolled

Genitourinary

Ototoxicity, Testicular Neoplasms, Neurotoxicity Syndromes

NCT01293851 2019-12-05

Molecular-Genetic Mechanisms Associated With Chemotherapy-Induced Nerve Damage

Terminated

3 enrolled

Neoplasms, Neuralgia, Neurotoxicity Syndromes

NCT00001807 2019-04-24

(1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy

50 enrolled

Phase EARLY_PHASE1 Completed

Brain Neoplasms, Neurotoxicity Syndromes

NCT00807768 2019-03-20

Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer

Phase 3 Unknown

601 enrolled 13 charts

Other

Fatigue, Obesity, Neurotoxicity Syndromes

NCT01372787 2019-03-12

Quality of Life and Care Needs of Patients With Persistent or Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Peritoneal Cancer

Unknown

103 enrolled

Gynecologic

Anxiety Disorders, Fallopian Tube Neoplasms, Fatigue, Nausea, Ovarian Neoplasms, Vomiting, Neurotoxicity Syndromes

NCT00452868 2018-09-07

Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain

14 enrolled 7 charts

Familial ependymoma, Astrocytoma, Medulloblastoma, Radiation Injuries, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neurotoxicity Syndromes, Optic Nerve Glioma

NCT00068445 2018-05-04

Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer

131 enrolled 14 charts

Pain, Neurotoxicity Syndromes

NCT01279681 2017-12-08

Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer

Phase 3 Terminated

32 enrolled 14 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Neurotoxicity Syndromes

NCT00755313 2017-11-24

Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer

81 enrolled

Breast Neoplasms, Fatigue, Neurotoxicity Syndromes

NCT01050075 2017-11-06

Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III Breast Cancer Who Are Receiving Paclitaxel

Phase NA Terminated

7 enrolled

Breast Neoplasms, Breast Neoplasms, Male, Neurotoxicity Syndromes

NCT03330964 2017-11-06

Clinical Trial of Electroacupuncture Stimulation on Prevention and Treatment of Oxaliplatin Neurotoxicity

Phase NA Unknown

120 enrolled

Gastrointestinal Neoplasms, Neurotoxicity Syndromes

NCT00754767 2017-09-11

L-Carnitine L-Tartrate in Preventing Peripheral Neuropathy Caused By Chemotherapy in Women With Metastatic Breast Cancer

Phase 4 Terminated

2 enrolled 3 charts

Breast Neoplasms, Neurotoxicity Syndromes

NCT00516503 2017-08-24

Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer

LymphoidMyeloidOther hematologic neoplasmPlasma cell

208 enrolled 12 charts

Leukemia, Lymphoma, Lymphoproliferative Disorders, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Pain, Neurotoxicity Syndromes, Neoplasms, Plasma Cell, Myelodysplastic-Myeloproliferative Diseases

NCT00566852 2017-08-21

Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors

554 enrolled 12 charts

Brain Neoplasms, Neoplasm Metastasis, Neurotoxicity Syndromes

NCT00775645 2017-08-14

S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo

437 enrolled 14 charts

Breast Neoplasms, Fatigue, Neurotoxicity Syndromes

NCT00437060 2017-07-21

Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia

233 enrolled

Neurotoxicity Syndromes

NCT01982591 2017-06-15

Heavy Metal Exposure in Predicting Peripheral Neuropathy in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy

115 enrolled

Breast Neoplasms, Peripheral Nervous System Diseases, Breast Neoplasms, Male, Neurotoxicity Syndromes

NCT00952848 2017-03-29

Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy

18 enrolled 10 charts

Pain, Peripheral Nervous System Diseases, Neurotoxicity Syndromes

NCT02311907 2017-02-23

Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

195 enrolled 12 charts

Gynecologic

Fallopian Tube Neoplasms, Ovarian Neoplasms, Pain, Neurotoxicity Syndromes

NCT00365768 2016-09-09

Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors

GenitourinaryLymphoidOther hematologic neoplasmSarcoma

56 enrolled 5 charts

Burkitt Lymphoma, Kidney Neoplasms, Leukemia, Lymphoma, Wilms Tumor, Peripheral Nervous System Diseases, Sarcoma, Lymphoma, Large B-Cell, Diffuse, Neuroectodermal Tumors, Primitive, Peripheral, Neurotoxicity Syndromes, Lymphoma, Extranodal NK-T-Cell, Dendritic Cell Sarcoma, Interdigitating

NCT00316914 2016-08-11

Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery

104 enrolled 15 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Neurotoxicity Syndromes

NCT00860041 2016-07-14

Acute Pain Caused by Paclitaxel in Patients With Cancer

306 enrolled

Pain, Neurotoxicity Syndromes

NCT00046891 2016-07-06

EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer

226 enrolled 12 charts

Breast Neoplasms, Neurotoxicity Syndromes

NCT00363129 2016-07-06

Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer

207 enrolled 13 charts

Neurotoxicity Syndromes

NCT00027963 2016-07-04

Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy