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Clinical Trials

9 trials
RecentStart dateEnrollment
EC145 × Clear all

Phase

Phase 2 6Phase 1 2Phase 3 1

Status

Completed 5Terminated 3Withdrawn 1

Sponsor Class

INDUSTRY 9

Study Type

Interventional 9

Sponsor

Cancer Type

Thoracic 3Gynecologic 3Other solid neoplasm 1Breast 1

Conditions

Neoplasms 5Ovarian Neoplasms 3Carcinoma, Non-Small-Cell Lung 3Adenocarcinoma 3Solid Tumor 1Endometrial Neoplasms 1Breast Neoplasms 1Advanced Cancer 1Adenocarcinoma of Lung 1

Interventions

Cyclophosphamide 2681Cisplatin 2665Carboplatin 2462Radiotherapy 2370Paclitaxel 2264Gemcitabine 2128pembrolizumab 1993Docetaxel 1883Bevacizumab 1821Fluorouracil 1548Capecitabine 1532Oxaliplatin 1440Dexamethasone 1330Nivolumab 1300Doxorubicin 1260Rituximab 1249Magnetic Resonance Spectroscopy 1150Etoposide 1126Irinotecan 1038Leucovorin 1020Drug Therapy 999Cytarabine 964Pemetrexed 891fludarabine 889Specimen Handling 822Vincristine 793Lenalidomide 791Cetuximab 785Prednisone 785Trastuzumab 785

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements
NCT01170650 2021-09-30

PROCEED

Endocyte

Phase 3 Terminated
441 enrolled
Gynecologic

Neoplasms, Ovarian Neoplasms

NCT01002924 2021-04-08

Extension Study of EC145 (Vintafolide) for Subjects Enrolled in a Previous Study With EC145 (MK-8109-010)

Endocyte

Phase 2 Completed
1 enrolled
Thoracic

Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT01577654 2021-04-01

TARGET

Endocyte

Phase 2 Completed
203 enrolled
Thoracic

Adenocarcinoma, Carcinoma, Non-Small-Cell Lung

NCT00511485 2015-02-27

Study of Vintafolide (MK-8109, EC145) in Participants With Progressive Adenocarcinoma of the Lung (MK-8109-008, EC-FV-03)

Endocyte

Phase 2 Completed
43 enrolled
Thoracic

Adenocarcinoma of Lung, Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT01688791 2015-02-10

A Study of MK-8109 (Vintafolide) Given Alone or With Chemotherapy in Participants With Advanced Cancers (MK-8109-001)

Endocyte

Phase 1 Terminated
37 enrolled

Advanced Cancer

NCT02049281 2015-02-10

A Study of Vintafolide (MK-8109) in Participants With Advanced Solid Tumor (MK-8109-011)

Endocyte

Phase 1 Terminated
3 enrolled
Other solid neoplasm

Solid Tumor

NCT00507741 2015-01-07

Study of Vintafolide (MK-8109, EC145) in Participants With Advanced Ovarian and Endometrial Cancers (MK-8109-007, EC-FV-02)

Endocyte

Phase 2 Completed
49 enrolled
Gynecologic

Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT00722592 2015-01-07

PRECEDENT

Endocyte

Phase 2 Completed
162 enrolled
Gynecologic

Neoplasms, Ovarian Neoplasms

NCT01953536 2014-12-19

Safety and Efficacy Study of Vintafolide and Vintafolide Plus Paclitaxel Compared to Paclitaxel Alone in Participants With Triple Negative Breast Cancer (TNBC) (MK-8109-004)

Endocyte

Phase 2 Withdrawn
Breast

Breast Neoplasms

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