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Clinical Trials

12 trials
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XL147 × Clear all

Phase

Phase 1 9Phase 1/2 2Phase 2 1

Status

Completed 11Withdrawn 1

Sponsor Class

INDUSTRY 12

Study Type

Interventional 12

Sponsor

Cancer Type

Tumor-Agnostic 3Thoracic 3Breast 3Gynecologic 2Other solid neoplasm 1Lymphoid 1CNS 1

Conditions

Neoplasms 6Carcinoma, Non-Small-Cell Lung 3Breast Neoplasms 3Endometrial Neoplasms 2Solid Tumor Cancers 1Ovarian Neoplasms 1Neoplasm Metastasis 1Lymphoma 1Glioblastoma 1

Interventions

Cyclophosphamide 2848Cisplatin 2837Carboplatin 2635Radiotherapy 2522Paclitaxel 2424Gemcitabine 2263pembrolizumab 2099Docetaxel 1978Bevacizumab 1966Fluorouracil 1660Capecitabine 1640Oxaliplatin 1551Dexamethasone 1417Nivolumab 1394Doxorubicin 1349Rituximab 1338Magnetic Resonance Spectroscopy 1229Etoposide 1198Irinotecan 1122Leucovorin 1096Drug Therapy 1062Cytarabine 1010Pemetrexed 944fludarabine 933Specimen Handling 875Vincristine 857Prednisone 851Lenalidomide 838Trastuzumab 837Cetuximab 831

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements
NCT01013324 2016-06-03

Study of XL147 (SAR245408) in Advanced or Recurrent Endometrial Carcinoma

Sanofi

Phase 2 Completed
67 enrolled
Gynecologic

Endometrial Neoplasms

NCT01042925 2016-06-03

Study of XL147 (SAR245408) in Combination With Trastuzumab or Paclitaxel and Trastuzumab in Subjects With Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab-based Regimen

Sanofi

Phase 1/2 Completed
42 enrolled
Breast

Breast Neoplasms

NCT01082068 2016-06-03

Study of XL147 (SAR245408) or XL765 (SAR245409) in Combination With Letrozole in Subjects With Breast Cancer

Sanofi

Phase 1/2 Completed
72 enrolled
Breast

Breast Neoplasms

NCT01943838 2016-04-22

A Study of the Safety and Pharmacokinetics of SAR245408 Tablets in Patients With Solid Tumors or Lymphoma

Sanofi

Phase 1 Completed
18 enrolled
Tumor-Agnostic

Neoplasms

NCT01357330 2016-04-01

Oral SAR245408 (XL147) and Oral MSC1936369B in Patients With Locally Advanced or Metastatic Solid Tumors

Sanofi

Phase 1 Completed
18 enrolled
Tumor-Agnostic

Neoplasm Metastasis

NCT00704392 2015-08-20

Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid Tumors

Exelixis

Phase 1 Withdrawn
BreastThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT01392924 2014-12-03

Safety and Pharmacokinetics of SAR245408 Daily Oral in Patients With Solid Tumors

Sanofi

Phase 1 Completed
10 enrolled
Tumor-Agnostic

Neoplasms

NCT01436565 2014-06-13

A Study of Investigational SAR256212 in Combination With SAR245408 in Patients With Solid Tumor Cancers

Sanofi

Phase 1 Completed
26 enrolled
Other solid neoplasm

Solid Tumor Cancers

NCT00756847 2013-04-10

Safety Study of XL147 (SAR245408), in Combination With Paclitaxel and Carboplatin in Adults With Solid Tumors

Sanofi

Phase 1 Completed
52 enrolled
GynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT00486135 2013-02-01

Study of the Safety and Pharmacokinetics of XL147 (SAR245408) in Adults With Solid Tumors or Lymphoma

Sanofi

Phase 1 Completed
118 enrolled
Lymphoid

Lymphoma, Neoplasms

NCT01240460 2012-07-27

Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical Resection

Sanofi

Phase 1 Completed
40 enrolled
CNS

Glioblastoma

NCT00692640 2012-03-23

Safety Study of XL147 (SAR245408) in Combination With Erlotinib in Adults With Solid Tumors

Sanofi

Phase 1 Completed
35 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms

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