Clinical Trials

Uveal Melanoma

NCT02159989 2025-10-20

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

GastrointestinalGynecologic

83 enrolled 21 charts

Fibrolamellar hepatocellular carcinoma, Adenoma, Islet Cell, Neoplasm Metastasis, Ovarian Neoplasms

NCT03712904 2025-09-24

Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma

Phase 2 Terminated

3 enrolled 9 charts

Uveal Melanoma

NCT00532155 2025-09-10

VITAL

913 enrolled 16 charts

Thoracic

Carcinoma, Lung Neoplasms

NCT03186326 2025-06-29

SAMCO

132 enrolled

Colorectal Neoplasms

NCT03172299 2025-03-24

PROTECT

57 enrolled

Uveal Melanoma

NCT01652196 2025-02-05

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

56 enrolled 14 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT03730558 2025-01-22

ZETA

Completed

120 enrolled

Colonic Neoplasms, Neoplasm Metastasis

NCT02384759 2024-07-10

FOLFA

117 enrolled 12 charts

Colorectal Neoplasms

NCT00407654 2024-03-04

VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer

75 enrolled 15 charts

Colonic Neoplasms, Rectal Neoplasms

NCT03530267 2024-02-23

ELDERLY

124 enrolled

Colorectal Neoplasms

NCT01782443 2023-08-14

Ziv-Aflibercept for Advanced Progressive Carcinoid Tumors

19 enrolled 11 charts

Endocrine

Carcinoid Tumor, Neoplasm Metastasis

NCT03279289 2023-04-13

AFEMA

170 enrolled

Colorectal Neoplasms

NCT03043729 2023-02-06

mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer

119 enrolled

Rectal Neoplasms

NCT03710564 2023-01-30

MERLIN

Phase 3 Terminated

535 enrolled 14 charts

CNS

Macular Degeneration, Neurofibromatosis 2

NCT02181556 2021-06-07

Efficacy and Safety of Aflibercept in Combination With FOLFIRI Chemotherapy as 1st Line Treatment for Patients With Metastatic Colorectal Cancer

41 enrolled 8 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT02340949 2021-05-03

RIA

180 enrolled 15 charts

Rectal Neoplasms

NCT04810585 2021-03-23

Plasma Biomarker for Aflibercept in Advanced Colorectal Cancer

Phase 4 Unknown

153 enrolled

Recurrence, Colorectal Neoplasms

NCT00794417 2020-12-10

A Study of Aflibercept Administered in Combination With Pemetrexed and Cisplatin in Participants With Advanced Carcinoma

Phase 1/2 Terminated

60 enrolled 24 charts

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02101918 2020-03-23

Ziv-Aflibercept in Treating and Computed Tomography Perfusion Imaging in Predicting Response in Patients With Pancreatic Neuroendocrine Tumors That Are Metastatic or Cannot Be Removed by Surgery

22 enrolled 10 charts

Endocrine

Somatostatinoma, Multiple Endocrine Neoplasia Type 1

NCT01669720 2020-02-17

C261

Phase 2 Terminated

10 enrolled 7 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT01747551 2020-02-10

FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer

64 enrolled 11 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT04252456 2020-02-05

DISTINCTIVE

Phase NA Unknown

150 enrolled

Advanced Colorectal Cancer

NCT02331927 2019-09-20

PERMAD

Phase 2 Unknown

150 enrolled

Colorectal Neoplasms

NCT00462826 2019-07-23

VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer

49 enrolled 13 charts

Gynecologic

Endometrial Neoplasms

NCT01258855 2019-05-10

Aldesleukin With or Without Ziv-Aflibercept in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

84 enrolled 13 charts

Melanoma

NCT03923036 2019-04-22

AVOCETTE

Unknown

2,000 enrolled

Colorectal Cancer Metastatic

NCT00436501 2019-02-26

VEGF Trap and Docetaxel in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Phase 1/2 Completed

58 enrolled 16 charts

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

NCT02624726 2019-02-22

MINOAS

Phase 2 Unknown

31 enrolled

Colorectal Neoplasms

NCT01661972 2018-10-29

X-TRAP

Phase 1/2 Completed

63 enrolled 12 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT00450255 2018-05-24

VEGF Trap in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

41 enrolled 7 charts

Uveal Melanoma, Melanoma

NCT01571284 2018-04-17

Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen

781 enrolled 28 charts

Colorectal Cancer Metastatic

NCT02192541 2018-03-29

Ganetespib and Ziv-Aflibercept in Refractory Gastrointestinal Carcinomas, Non-Squamous Non-Small Cell Lung Carcinomas, Urothelial Carcinomas, and Sarcomas

Phase 1 Terminated

5 enrolled 15 charts

Sarcoma

Neoplasms, Sarcoma

NCT02129257 2017-10-24

AMALTHEA

73 enrolled

Colorectal Neoplasms

NCT03264274 2017-08-31

AUSCOR

Phase 2 Withdrawn

Neoplasm Metastasis, Colorectal Neoplasms

NCT00828139 2017-08-21

S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer

189 enrolled 15 charts

Thoracic

Small Cell Lung Carcinoma

NCT02079220 2017-07-31

A Phase II Study of Ziv-aflibercept in Combination With Capecitabine/Oxaliplatin (XELOX) Chemotherapy in the Front-Line Treatment of Patients With Metastatic Colorectal Cancer

Phase 2 Withdrawn

Colorectal Neoplasms

NCT00357760 2017-06-23

Ziv-Aflibercept in Treating Patients With Metastatic or Unresectable Kidney Cancer

94 enrolled 8 charts

Genitourinary

Carcinoma, Renal Cell

NCT01646554 2017-05-09

BOS3

Phase 2/3 Withdrawn

Colorectal Neoplasms

NCT01882868 2017-03-14

A Study of Aflibercept in Combination With FOLFIRI in Patients With Second-Line Metastatic Colorectal Cancer in Japan

62 enrolled 34 charts

Colorectal Cancer Metastatic

NCT01749956 2017-02-07

5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer

39 enrolled 13 charts

Rectal Neoplasms

NCT02045030 2016-11-16

Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With Metastatic Colorectal Cancer

Phase 2 Terminated

14 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT00519285 2016-07-22

VENICE

1,224 enrolled 21 charts

Genitourinary

Neoplasm Metastasis, Neoplasms, Prostatic Neoplasms

NCT00574275 2016-06-07

VANILLA

Phase 3 Terminated

546 enrolled 14 charts

Pancreatic Neoplasms

NCT00036946 2016-06-03

VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00045266 2016-06-03

VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00082823 2016-06-03

Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma

GastrointestinalGenitourinaryGynecologicLymphoidOther hematologic neoplasmSarcoma

25 enrolled

Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Burkitt Lymphoma, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Sarcoma, Testicular Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Endometrial Neoplasms, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00083213 2016-06-03

Intravenous VEGF Trap in Treating Patients With Relapsed or Refractory Advanced Solid Tumors or Non-Hodgkin's Lymphoma