Clinical Trials

Phase 1/2 Not yet recruiting

Breast Neoplasms

NCT07261592 2025-12-03

Entinostat & Chemotherapy for Locally Advanced or Metastatic Bladder Cancer

29 enrolled

Phase 2 Not yet recruiting

Urinary Bladder Neoplasms

NCT07235618 2025-11-19

A Study of Entinostat in Combination With Fulvestrant for the Treatment of Locally Advanced or Metastatic Breast Cancer

50 enrolled

Breast Neoplasms

NCT03280563 2025-11-10

MORPHEUS HR+BC

144 enrolled 25 charts

Phase 2 Active not recruiting

Breast Neoplasms

NCT03978624 2025-10-15

Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer

20 enrolled 11 charts

Urinary Bladder Neoplasms

NCT04631029 2025-10-03

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

Phase 2 Active not recruiting

3 enrolled 12 charts

CNS

Brain Neoplasms

NCT03179930 2025-07-23

Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas

47 enrolled

Lymphoid

Lymphoma, Recurrence

NCT03250273 2025-05-28

A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma

44 enrolled 19 charts

Neoplasm Metastasis, Pancreatic Neoplasms, Cholangiocarcinoma

NCT01349959 2025-04-27

Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer

58 enrolled 16 charts

Breast Neoplasms, Breast Neoplasms, Male, Triple Negative Breast Neoplasms

NCT02437136 2025-03-20

Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

191 enrolled 26 charts

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Melanoma

NCT03024437 2025-03-20

Atezolizumab in Combination With Entinostat and Bevacizumab in Patients With Advanced Renal Cell Carcinoma

Phase 1/2 Terminated

31 enrolled 19 charts

Kidney Neoplasms, Neoplasm Metastasis

NCT02708680 2024-12-04

Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead In

89 enrolled 16 charts

Breast Neoplasms

NCT03552380 2024-09-03

Study of Entinostat With Nivolumab Plus Ipilimumab in Previously Treated Renal Cell Carcinoma

12 enrolled 16 charts

Carcinoma, Renal Cell

NCT05898828 2024-08-05

Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer

Phase 1/2 Withdrawn

Esophageal Neoplasms, Neoplasms

NCT02915523 2024-01-10

Study of Avelumab With or Without Entinostat in Participants With Advanced Epithelial Ovarian Cancer

140 enrolled 25 charts

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Ovarian Diseases, Ovarian Neoplasms

NCT03765229 2024-01-10

An Exploratory Study of Pembrolizumab Plus Entinostat in Non-Inflamed Stage III/IV Melanoma

11 enrolled 12 charts

Dermatologic

Melanoma

NCT02697630 2023-12-08

PEMDAC

29 enrolled

Dermatologic

Uveal Melanoma

NCT03215264 2023-11-09

To Determine the Safety of Regorafenib, Hydroxychloroquine, and Entinostat Metastatic Colorectal Cancer

20 enrolled 9 charts

Colorectal Neoplasms

NCT02780804 2023-10-17

Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

Phase 2 Active not recruiting

21 enrolled 15 charts

CNSLymphoid

Lymphoma, Pinealoma, Central Nervous System Neoplasms, Brain Stem Neoplasms

NCT03501381 2023-09-01

High Dose IL 2 and Entinostat in RCC

46 enrolled

Carcinoma, Renal Cell

NCT00750698 2023-07-06

A Phase 2 Exploratory Study of Erlotinib and SNDX-275 in Participants With Non-small Cell Lung Carcinoma Who Are Progressing on Erlotinib

8 enrolled 6 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03473639 2022-11-01

Breast49

13 enrolled

Breast Neoplasms

NCT02623751 2022-06-21

Study of KHK2375 in Subjects With Advanced or Recurrent Breast Cancer

15 enrolled

Breast Neoplasms

NCT03291886 2022-06-21

Phase 2 Study of KHK2375 in Subjects With Advanced or Recurrent Breast Cancer

133 enrolled

Breast Neoplasms

NCT00754312 2022-06-06

A Phase I, Multicenter, Open Label Study on the Effects of SNDX-275 on Expression of Biomarkers in Subjects With Newly Diagnosed Breast Cancer

1 enrolled

Breast Neoplasms

NCT01234532 2022-05-03

0927GCC

5 enrolled 7 charts

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT02897778 2022-04-28

Cardiac Safety Study of Entinostat in Men and Women With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryThoracic

30 enrolled

Breast Diseases, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Non-Small-Cell Lung, Digestive System Neoplasms, Endocrine Gland Neoplasms, Kidney Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Glandular and Epithelial, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT02909452 2022-01-25

Continuation Study of Entinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryThoracic

30 enrolled

Breast Diseases, Bronchial Neoplasms, Carcinoma, Non-Small-Cell Lung, Digestive System Neoplasms, Endocrine Gland Neoplasms, Kidney Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Glandular and Epithelial, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT04296942 2022-01-11

BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT)

1 enrolled 10 charts

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT02820961 2021-12-15

Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer

61 enrolled

Breast Diseases, Breast Neoplasms

NCT03829930 2021-08-02

Combination of Entinostat and Enzalutamide in Advanced Prostate Cancer

6 enrolled

Prostate Adenocarcinoma

NCT03538171 2021-07-09

Ph3 Study of Exemestane With or Without Entinostat in Chinese Patients With Hormone Receptor-Positive, Locally Advanced or Metastatic Breast Cancer

Phase 3 Unknown

375 enrolled

Advanced Breast Cancer

NCT03760614 2021-01-15

A Study of Entinostat and FOLFOX in Subjects With Pancreatic Adenocarcinoma

Phase 1 Withdrawn

Pancreatic Neoplasms

NCT03925428 2020-09-28

Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas

Phase 1 Withdrawn

GastrointestinalLymphoid

Lymphoma, Pancreatic Neoplasms, Lymphoma, B-Cell, Lymphoma, T-Cell

NCT00866333 2019-10-22

ENGAGE-501

49 enrolled 12 charts

Lymphoid

Hodgkin Disease

NCT00101179 2019-10-18

MS-275 and Azacitidine in Treating Patients With Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia

MyeloidOther hematologic neoplasm

63 enrolled

Leukemia, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic

NCT01434303 2019-05-20

Entinostat, Lapatinib Ditosylate and Trastuzumab in Treating Patients With Locally Recurrent or Distant Relapsed Metastatic Breast Cancer Previously Treated With Trastuzumab Only

37 enrolled

Breast Neoplasms

NCT00387465 2019-05-09

Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung Cancer

94 enrolled 18 charts

Carcinoma, Non-Small-Cell Lung

NCT02833155 2019-05-07

Entinostat in Chinese Postmenopausal Women Patients With Locally Recurrent or Metastatic Breast Cancer

19 enrolled

Breast Neoplasms

NCT01207726 2019-02-05

Azacitidine and Entinostat in Treating Patients With Stage I Non-Small Cell Lung Cancer That Has Been Removed By Surgery

13 enrolled 5 charts

Carcinoma, Non-Small-Cell Lung

NCT01935947 2018-07-27

Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer

17 enrolled 10 charts

LymphoidOther hematologic neoplasm

Carcinoma, Non-Small-Cell Lung

NCT01383447 2017-08-08

Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Phase 1/2 Terminated

2 enrolled 4 charts

Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT01886573 2016-11-18

Azacitidine and Entinostat in Treating Patients With Newly Diagnosed Stage IA-IIIA Non-Small Lung Cancer Undergoing Surgery

40 enrolled

Carcinoma, Non-Small-Cell Lung

NCT00185302 2015-12-14

Safety and Efficacy Study of a New Chemotherapy Agent to Treat Metastatic Melanoma